Rare Ophthalmology News
Advertisement
Disease Profile
Interstitial cystitis
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
#N/A
Age of onset
#N/A
ICD-10
#N/A
Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
IC; Pelvic pain syndrome; Trigonitis;
Categories
Kidney and Urinary Diseases
Summary
Interstitial cystitis (IC) is a chronic condition that causes painful urinary symptoms. Symptoms and severity can vary. Some people may have only mild discomfort, or feel tenderness or pressure in the bladder or pelvis. Others may experience intense bladder pain, urgent or frequent needs to urinate, or pain during sexual intercourse.[1][2] Symptoms may be constant, or they may come and go.[3] Some people with IC have Hunner's ulcers (areas of inflammation on the bladder wall, identified by cytoscopy).[4]
The exact cause of IC is not known.[1][2] While the symptoms are similar to those of a bladder infection, IC is not an infection.[3] It occurs more commonly in women, and in people with other chronic pain disorders such as irritable bowel syndrome or fibromyalgia.[2]
There is no cure for IC, but there are treatment options to help relieve the symptoms.[5] No single treatment works for all people with IC. Often, people try different treatments or combinations of treatments before finding something that works.[2][3] Treatment options may include lifestyle changes, oral or topical medications, bladder instillations, neuromodulation therapy, Botox injections in the bladder muscles, and surgery (in rare cases).[3][5] Without treatment, IC can affect a person's sleep, daily activities, and social life.[3]
Symptoms
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
Medical Terms | Other Names |
Learn More:
HPO ID
|
---|---|---|
80%-99% of people have these symptoms | ||
Abnormality of the labia | 0000058 | |
Abnormality of the menstrual cycle | 0000140 | |
Abnormality of the urethra |
Urethra issue
|
0000795 |
Dyspareunia | 0030016 | |
Nocturia | 0000017 | |
Pain | 0012531 | |
Pollakisuria |
Frequent urination
|
0100515 |
Urinary bladder inflammation | 0100577 | |
Urinary urgency |
Overactive bladder
|
0000012 |
5%-29% of people have these symptoms | ||
Abnormal vagina morphology | 0000142 |
Treatment
FDA-Approved Treatments
The medication(s) listed below have been approved by the Food and Drug Administration (FDA) as orphan products for treatment of this condition. Learn more orphan products.
- Pentosan polysulfate sodium(Brand name: Elmiron) Manufactured by Janssen Pharmaceuticals, Inc
FDA-approved indication: Relief of bladder pain or discomfort associated with interstitial cystitis.
National Library of Medicine Drug Information Portal
Medline Plus Health Information
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Organizations Supporting this Disease
-
Interstitial Cystitis Association
7918 Jones Branch Drive, Suite 300
McLean, VA 22102
Telephone: 703-442-2070
E-mail: [email protected]
Website: https://www.ichelp.org -
Urology Care Foundation
1000 Corporate Boulevard
Linthicum, MD 21090
Toll-free: 1–800–828–7866
Telephone: 410–689–3990
Fax: 410–689–3998
E-mail: [email protected]
Website: https://www.urologyhealth.org
Organizations Providing General Support
-
American Autoimmune Related Diseases Association (AARDA)
19176 Hall Road, Suite 130
Clinton Township, MI 48038
Toll-free: 800-598-4668
Telephone: 586-776-3900
Fax: 586-776-3903
E-mail: [email protected]
Website: https://www.aarda.org/
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- Mayo Clinic has an information page on Interstitial cystitis.
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The Merck Manual provides information on this condition for patients and caregivers.
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) provides information on this topic.
- The National Kidney Foundation offers an information page on Interstitial cystitis.
- The The Cleveland Clinic Web site has an information page on Interstitial cystitis. Click on the Cleveland Clinic link to view this page.
- The Urology Care Foundation offers an information page on Interstitial cystitis. Please click on the link to access this resource.
In-Depth Information
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Merck Manual for health care professionals provides information on Interstitial cystitis.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
References
- Interstitial Cystitis (Painful Bladder Syndrome). National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). July, 2017; https://www.niddk.nih.gov/health-information/urologic-diseases/interstitial-cystitis-painful-bladder-syndrome/all-content.
- Interstitial cystitis. Mayo Clinic. August 12, 2017; https://www.mayoclinic.org/diseases-conditions/interstitial-cystitis/symptoms-causes/syc-20354357.
- Interstitial Cystitis. Urology Care Foundation. https://www.urologyhealth.org/urologic-conditions/interstitial-cystitis. Accessed 10/4/2017.
- Hunner's Ulcers. Interstitial Cystitis Association. March, 2015; https://www.ichelp.org/about-ic/symptoms-of-ic/hunners-ulcers/.
- IC Treatments. Interstitial Cystitis Association. January, 2013; https://www.ichelp.org/diagnosis-treatment/treatments/.